What is Purpura Nephritis?
Purpura Nephritis (also known as Anaphylactoid Purpura Nephritis) is a kidney disease that caused by Henoch-Schonlein Purpura (HSP). It is generally considered as an immune complex-mediated disease characterized by the presence of polymerix IgA. Pathological changes of purpura Nephritis focus on mesangial proliferation, necrosis of focal glomerular capillary loops and formation of crescents. Besides, in mesangial area as well as the surrounding area, deposition of IgA and other immune globulin can be found.
What are causes of Purpura Nephritis?
When people suffer from Purpura Nephritis, there are IgA immune complexes and other immune complexes in mesangial area founded. Also, the distribution of IgG and IgM is the same with the distribution of IgA. All these showed that patients with purpua nephritis are suffering from dysfunction. IgA and other immune complex can cause immoderate inflammatory reaction and thus impair our kidney cells causing reduction of kidney function. Hence, the root cause of Purpura Nephritis is closely related with abnormal immune system.
What are symptoms of Purpura Nephritis?
Purpura Nephritis symptoms vary from person to person and in some patients, they may live the disease for a long time without realization. The following are some common symptoms of purpura nephritis for your reference.
- High blood pressure
- Stomachache
- Joint pain
- Rash
- Edema
What should be treatment for Purpura Nephritis?
- Steroid Therapy
Steroid therapy is the most commonly used treatment for both acute and chronic diseases, especially to suppress inflammation. Steroid therapy is mainly used to treat the symptoms of purpura nephritis, such as proteinuria, swelling, and blood in urine, etc.
- Traditional Chinese Medicine
Traditional Chinese Medicine (TCM) was established more than 5000 years ago. This therapy is characterized with natural pattern and low side effects. TCM helps deal with the symptoms of purpura nephritis and improve kidney functions.
There are various types of Chinese therapies, such as Chinese herbal medicine, acupuncture, massage, Micro-Chinese Medicine Osmotherapy, full bath, foot bath, and so on. Based on the specific illness condition of patients, different therapies will be used. And these therapies aim at repairing kidney damage and improving renal function from root.
- Immunotherapy
Immunotherapy currently is suggested by many doctors for its systemic effects, which uses special tests to evaluate the medical conditions and uses low side effects steroids to control kidney inflammation; Besides, some blood purification techniques may also be used to cleanse the purpura or other toxins, immune complexes in the blood. And TCM is also involved to repair the damaged tissues and improve kidney functions.
What is the prognosis with Purpura Nephritis?
Overall prognosis is good in most patients, with one study showing recovery occurring in 94% and 89% of children and adults, respectively (some having needed treatment). In children under ten, the condition recurs in about a third of all cases and usually within the first four months after the initial attack. Recurrence is more common in older children and adults.
